Cutbacks at Pfizer. Sometimes it was known as the ‘Pfizer rule of five’ or ‘Lipinski’s rule of five’, for the understandable reason that its originator, Chris Lipinski, worked at Pfizer. President Trump and some public health experts say encouraging early results from Pfizer and Moderna suggest the approach is working. ... Derek Lowe… Pfizer announced Monday that early data shows its vaccine has a more than 90% success rate. But it wasn’t just one rule, it was several … But the production process is in its infancy, requiring special machinery that is in short supply. Derek Lowe says: 7 April, 2021 at 2:12 pm That’s a good paper on this subject, but I note that it ends up recommended proceeding with Ad26-platform vaccines in these regions, though. But Pfizer's and Moderna's vaccines use new mRNA technology, which made it possible to roll them out with unprecedented speed. We know that the two mRNA vaccines from Pfizer/BioNTech and Moderna have gotten emergency approval and their deployment has started in … Commentary by Derek Lowe at Science Translational Medicine on Small Molecule Clinical Data . The word is that Pfizer has decided to exit neuroscience completely. By Derek Lowe January 5, 2018. This article by Derek Lowe on the blog-website of Science Magazine outlines some of the challenges of vaccine manufacturing, specifically of the Moderna and BioNTech/Pfizer vaccines.. ... said drug discovery chemist Derek Lowe, because many … Derek Lowe; April 17, 2009 Age Before Beauty, Revisited. He reminded us that: The takeaway is that there are some bottlenecks in the process that require complex manufacturing technology that can't be easily put in operation by just sharing the formula. This is because pretty much all of the vaccines in development target the same virus component that Pfizer / BioNTech’s does: the spike protein. To contact Derek, email him directly: derekb.lowe@gmail.com (mailto:derekb.lowe@gmail.com) Summary Pfizer/BioNTech released more data about their actual coronavirus vaccine candidate, BNT162b2. I’m told there there are many layoffs involved, although the company itself does not seem to have made any announcement. Derek Lowe is already on top of this news (of course he is), and he points out that these strong results from Pfizer’s candidate bode extremely well for the entire worldwide vaccine effort. Early evidence from Israel suggests that the Pfizer vaccines are working. Derek Lowe writes a column in Science Translational Medicine each week that I have found to be informative and readable, and this week has provided a vaccine roundup at the end of December which I'll briefly summarize and comment on here. Derek Lowe; April 17, 2009 Is The Blockbuster Era Over for Big Pharma? 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